Jamie Fornsaglio PhD

 
 
Associate Professor of Biology
Seton Hill Faculty
 
 

About

Joined Seton Hill: 2005
Hometown: Delmont, PA
Personal Areas of Interest:
Academic Areas of Interest: My research interests are in understanding the mechanisms involved in repairing DNA insult caused by a variety of DNA damaging agents. The courses I teach at SHU are: Genetics and Genetics Laboratory, Medical Genetics, Cell Biology and Cell Biology Laboratory, Molecular Biology and Molecular Biology Laboratory, and Biology Seminar

Education

  • Ph.D. in Molecular and Cellular Oncology, The George Washington University (Washington, DC), 2004
  • B.A. in Biology, Washington and Jefferson College (Washington, PA), 1998

Publications

  • Choi YJ, Li H, Son MY, Wang X-h, Fornsaglio JL, Sobol RW, Lee M, Vijg J, Imholz S, T. Dolle ME, vanSteeg, H, Reiling E, and Hasty P. 2014. Deletion of Individual Ku Subunits in Mice Causes an NHEJ-Independent Phenotype Potentially by Altering Apurinic/Apyrimidinic Site Repair. PLoS ONE 9(1): e86358. [More Information]
  • Momcilovic O, Knobloch L, Fornsaglio J, Varum S, Easley C, and Schatten G. 2010. DNA damage responses in human induced pluripotent stem cells and embryonic stem cells. PLoS ONE. 5(10): e13410. doi:10.1371/journal.pone.0013410 [More Information]
  • McCormick KD, Knobloch LJ, Whitebread EA, Howatch NJ, Yochum S, and Fornsaglio JL. 2010. Toxicity in wild type and DNA repair deficient Saccharomyces cerevisiae following exposure to chemicals utilized in aviation. Journal of the Pennsylvania Academy of Sciences. 84(1); 17-25.
  • Jelezcova E, Trivedi RN, Wang XH, Tang JB, Brown AR, Goellner EM, Schamus S, Fornsaglio JL and Sobol RW. 2010. Parp1 activation in mouse embryonic fibroblasts promotes Pol ß-dependent cellular hypersensitivity to alkylation damage. Mutat Res. 686(1-2); 57-67.
  • Trivedi RN, Almeida KH, Fornsaglio JL, Schamus S, and Sobol RW. 2005. The role of base excision repair in the sensitivity and resistance to temozolomide-mediated cell death. Cancer Res. 65(14):6394-6400.
  • Pritchard DE, Ceryak S, Ramsey KE, O’Brien TJ, Ha L, Fornsaglio JL, Stephan DA, and Patierno SR. 2005. Resistance to apoptosis, increased growth potential, and altered gene expression in cells that survived genotoxic hexavalent chromium [Cr(VI)] exposure. Mol Cell Biochem. 279(1-2): 169-181.
  • Fornsaglio JL, O’Brien TJ, and Patierno SR. (2005) Differential impact of ionic and coordinate covalent Cr-DNA binding on DNA replication. Mol Cell Biochem. 279(1-2): 149-155.
  • Vilcheck SK, O’Brien TJ, Pritchard DE, Ha L, Ceryak S, Fornsaglio JL, and Patierno SR. (2002) Fanconi anemia complementation group A cells are hypersensitive to chromium(VI)-induced toxicity. Environ. Health Perspect. 110(5): 773-7.
  • O’Brien, T.J., Fornsaglio, J.L., Ceryak, S. and Patierno, S.R. (2002) Effects of hexavalent chromium on the survival and cell cycle distribution of DNA repair- deficient S. cerevisiae. DNA Repair 1: 617-627.
  • Pritchard DE, Ceryak S, Ha L, Fornsaglio JL, Hartman SK, O’Brien TJ, and Patierno SR. (2001) Mechanism of apoptosis and determination of cellular fate in chromium(VI)-exposed populations of telomerase-immortalized human fibroblasts Cell Growth Differ 12: 487-496.

Awards

  • PI of National Science Foundation (NSF) grant- “Implementation of Design-Based Learning and Interdisciplinary Collaborative Strategies for Enhancing Learning in Laboratory Sciences (Summer 2013-Summer 2016) [More Information]
  • Recipient of a supplemental grant to study the pluripotent stem cell response to DNA damage in response to the American Recovery and Reinvestment Act (ARRA) of 2009. This supplemental grant was under the principle investigator Gerald Schatten, PhD and the parent grant titled, “Pluripotent Stem Cells in Development and Disease” at Magee-Womens Research Institute. (2009)
  • 1st place: The George Washington Heath Science Research Day Poster Presentation Competition (2002)

Organizations

  • West Virginia IDeA Network of Biomedical Research Excellence (WV-INBRE) External Advisory Committee (EAC)
  • Active member of American Association of Cancer Research

Presentations

  • Advised student poster presentation: Schroeder, A, Lackey, M, and Geary, K. The Effects of Caffeine on NIH3T3 Mouse Fibroblast Cells. 34th Annual Western Pennsylvania Biology Undergraduate Research Symposium, March 2013
  • Advised student poster presentation: Howatch N, McCormick K, Fornsaglio J , and Yochum S. Effects of tert-butyl hydroperoxide on wild type and DNA repair deficient Saccharomyces cervisiae. 23rd American Chemical Society Meeting and Exposition; Washington, DC. August 2009
  • Advised student poster presentation: Whitebread E, Knobloch L. Turboline FS100 toxicity in wild-type and DNA repair deficient Saccharomyces cerevisiae. 29th Annual Western Pennsylvania Biology Undergraduate Research Symposium, March 2008.
  • Advised student poster presentation: Howatch N. Effects of tert-butyl hydroperoxide on wildtype and DNA-repair deficient Saccharomyces cerevisiae. 29th Annual Western Pennsylvania Biology Undergraduate Research Symposium, March 2008.
  • Advised student poster presentation: Pasipanki C, McCormick K. Clonogenic Survival of wild-type and DNA repair deficient Sacchromyces cerevisiae following exposure to diEGME. 29th Annual Western Pennsylvania Biology Undergraduate Research Symposium, March 2008.
  • Advised student poster presentation: McCormick K, Fornsaglio J. Toxicity and mutagenesis in wild-type and DNA repair deficient Saccharomyces cerevisiae following exposure to chemicals utilized in aviation. 28th Annual Western Pennsylvania Biology Undergraduate Research Symposium, March 2007.
  • Momcilovic O, Knobloch L, Fornsaglio J, Choi S, Bakkenist C, Schatten G. DNA Damage Repair in Human Embryonic Stem Cells. (poster presented by Olga Momcilovic). International Society for Stem Cell Research meeting; June 2010
  • Fornsaglio JL, O’Brien TJ, Patierno SR. Rad52-mediated homologous recombination is required for the resolution of double strand break intermediates generated by interstrand crosslink repair. Proceedings of the American Association for Cancer Research # 1566, March 2004
  • Pritchard DE, Pearson KE, Fornsaglio JL, Ha L, Ceryak S, Stephan DA, and Patierno SR. Micro array analysis reveals altered gene expression in apoptosis-resistant cells that survived genotoxic [chromium (VI)] insult. Proceedings of the American Association for Cancer Research # 5979, July 2003.
  • Fornsaglio JL, O’Brien TJ, Pritchard DE, Ha L, and Patierno SR. BRCA1 is crucial for survival and cell cycle progression following genotoxic insult with hexavalent Cr(VI). Proceedings of the American Association for Cancer Research #R430, July 2003.
  • Ha L, Ceryak S, Fornsaglio JL, Patierno SR. ATM is activated by DNA double strand breaks generated during recombinational repair of hexavalent chromium [Cr(VI)]-induced DNA damage. Environmental and Molecular Mutagenesis #71, May 2003.
  • O’Brien TJ, Fornsaglio, JL, Ceryak S, and Patierno SR. Chromium as a complex genotoxin: repair, replication and cellular response. 2nd Conference on Molecular Mechanisms of Metal Toxicity and Carcinogenesis, September 2002.
  • Fornsaglio JL, O’Brien TJ, and Patierno SR. Effects of Cr(VI) on polymerase processivity and polymerase arresting lesions in wildtype and DNA repair deficient S. cerevisiae. 2nd Conference on Molecular Mechanisms of Metal Toxicity and Carcinogenesis, September 2002.
  • O’Brien TJ, Fornsaglio JL, and Patierno SR. Exit from hexavalent chromium-induced G2 arrest requires RAD52-dependent recombinational repair in S. cerevisiae. Proceedings of the American Association for Cancer Research #5134, April 2002.
  • Fornsaglio JL, O’Brien TJ, and Patierno SR. Detection and quantitation of Cr(VI)-induced polymerase arresting lesions in DNA repair deficient S. cerevisiae: relationship to survival. Proceedings of the American Association for Cancer Research, #5132 April 2002.
  • Fornsaglio JL, O’Brien TJ, and Patierno SR. Effects of hexavalent chromium on S. cerevisiae deficient in DNA damage tolerance/repair: Implications of Rad52 for survival and Rev3 for mutagenesis. AACR-Pathobiology of Cancer Workshop, July 2001.
  • O’Brien TJ, Fornsaglio, JL, and Patierno SR. Sensitivity of DNA repair-deficient S. cerevisiae strains to hexavalent chromium. Toxicological Sciences Supplement, The Toxicologist 60(1), #1502, March 2001
  • Gornstein ER, Cataltepe S, Fornsaglio JL, Kumar V, Luke C, Pak S, Schick C, Tsu C, Uemura Y, Upton M, and Silverman G. Inflammation upregulates expression of the intracellular serpins SCCA1 and SCCA2. The American Pediatric Society and The Society for Pediatric Research, # 751376, 1999.

Performances

  • SHU Dancing with the Stars: Spring 2011 and Spring 2014

Certifications

  • On-line summer course: Foundations of Moodle 2.0 Course Development

Achievements

  • Applied as a Co-PI in an NIH training program to Broadening Experiences in Scientific Training (BEST) title, “Frontiers for Broadening Experiences in Scientific Training (BEST Frontiers): Advocacy, Diversity and Integration for Attractive Career Trajectories.” PI Gerald Schatten, Ph.D., Magee Womens Research Institute
  • iTunes U and iBooks author training August 2012
  • Selected to be a panelist at the Seton Hill University iTeach Conference Spring 2013
  • Attended Undergraduate Bioinformatics Education Conference: Summer 2011
  • Attended Metastasis and the Tumor Microenvironment Conference: September 2010
  • Selected to attend Frontiers in Human Embryonic Stem Cell Research Conference (Magee Women’s Hospital; Pittsburgh PA) (2007)
  • Chosen as Keynote Speaker at Women in Science Day, Seton Hill University (2006 and 2007)